Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

D G Batt; J J Petraitis; S R Sherk; R A Copeland; R L Dowling; T L Taylor; E A Jones; R L Magolda; B D Jaffee

doi:10.1016/s0960-894x(98)00308-4

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1745-50. doi: 10.1016/s0960-894x(98)00308-4.

Authors

D G Batt¹, J J Petraitis, S R Sherk, R A Copeland, R L Dowling, T L Taylor, E A Jones, R L Magolda, B D Jaffee

Affiliation

¹ DuPont Merck Pharmaceutical Company, Wilmington, Delaware 19880-0500, USA.

PMID: 9873427
DOI: 10.1016/s0960-894x(98)00308-4

Abstract

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.

MeSH terms

Biphenyl Compounds / chemistry
Carbon / chemistry
Immunosuppressive Agents / chemistry*
Immunosuppressive Agents / pharmacology*
Lymphocyte Culture Test, Mixed
Structure-Activity Relationship

Substances

Biphenyl Compounds
Immunosuppressive Agents
Carbon